Prevalence of osteoporosis in patients with nephrolithiasis and vice versa: a cumulative analysis
Prevalence of osteoporosis in patients with nephrolithiasis and vice versa: a cumulative analysis
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PurposeNephrolithiasis is thought to be a risk factor for osteoporosis, but data redken shades eq 07m driftwood assessing if osteoporosis predisposes to the risk of nephrolithiasis are lacking.The present study aims to investigate whether patients with nephrolithiasis have a prominently higher prevalence of osteoporosis than the controls and vice versa via a cumulative analysis.MethodsFour databases were used to detect the eligible studies.We calculated the relative risk (RR) with a 95% confidence interval (CI) to assess the combined effect.
The methodologies for conducting this study followed the PRISMA guidelines and were registered in the PROSPERO (ID: CRD42023395875),ResultsNine case-control or cohort studies with a total of 454,464 participants were finally included.Combined results indicated that there was a significantly higher prevalence of osteoporosis in patients with nephrolithiasis as compared to the general population without nephrolithiasis (overall RR from six studies= 1.204, 95%CI: 1.133 to 1.
28, P< 0.001; heterogeneity: I2 = 34.8%, P= 0.162).
Conversely, osteoporosis was significantly correlated to an increased risk of nephrolithiasis as compared to the controls without osteoporosis (overall RR from four studies= 1.505, 95%CI: 1.309 to 1.731, P< 0.
001; I2 = 89.8%, P< 0.001).Sensitivity analysis on the two categories validated the above findings.
No significant publication bias was identified here in this study.ConclusionsThe present study highlighted a significantly high prevalence of osteoporosis in patients with nephrolithiasis and vice versa.This reciprocal association reminded the clinicians to conduct a regular follow-up assessment when managing patients with nephrolithiasis or osteoporosis, especially for the elderly.Systematic review registrationhttps://www.
crd.york.ac.uk/PROSPERO/#searchadvanced, identifier CRD42023395875.